Fatal multisystemic toxicity associated with prophylaxis with pyrimethamine and sulfadoxine (Fansidar).
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چکیده
منابع مشابه
Unusual pulmonary reaction during short term prophylaxis with pyrimethamine-sulfadoxine (Fansidar).
'Klemp P, Staberg B, Madsbad S, Kolcndorf K. Smoking reduces insulin absorption from subcutaneous tissue. Br MedJ' 1982;284:237. 2 Binder C. Absorption of injected insulin. Acta Pharmacol Toxicol (Copenh) 1969 ;27(suppl 2): 1-84. 3Berger M, Cuppers HJ, Hegner H, Jorgens V, Berchtold P. Absorption kinetics and biologic effects of subcutaneously injected insulin preparations. Diabetes Care 1982;5...
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We conducted a prevalence study of mutations in Plasmodium falciparum that are associated with antifolate resistance in Blantyre, Malawi. The dihydrofolate reductase 164-Leu mutation, which confers resistance to both pyrimethamine and chlorproguanil, was found in 4.7% of the samples. Previously unreported mutations in dihydropteroate synthase were also found.
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چکیده ندارد.
Tolerance and haematological findings with antimalarials (chloroquine and Fansidar [pyrimethamine plus sulfadoxine]) in adults and children during field trials in Nigeria.
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متن کاملRapid real-time PCR genotyping of mutations associated with sulfadoxine-pyrimethamine resistance in Plasmodium falciparum.
The resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine (SP) is an emerging public health threat. Resistance to these drugs is associated with point mutations in the genes encoding dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR). We describe here an assay using real-time PCR and sequence-specific probes that detects these mutations. Using DNA from plasmids, cultu...
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ژورنال
عنوان ژورنال: BMJ
سال: 1985
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.290.6462.113-a